[Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019].
Identifieur interne : 000019 ( Main/Exploration ); précédent : 000018; suivant : 000020[Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019].
Auteurs : Jiahao Zhang [République populaire de Chine] ; Juan Li [Oman] ; Lianjiu Su [République populaire de Chine] ; Jie Yang [Oman] ; Xiaofang Jiang [République populaire de Chine] ; Nanhui Jiang [République populaire de Chine] ; Yu Lei [Oman] ; Li He [République populaire de Chine] ; Qiaofa Lu [Oman] ; Sanying Shen [Oman] ; Fan Chen [Oman] ; Zhiyong Peng [République populaire de Chine]Source :
- Zhonghua wei zhong bing ji jiu yi xue [ 2095-4352 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- étiologie : Atteinte rénale aigüe.
- complications : Betacoronavirus, Courbe ROC, Facteurs de risque, Humains, Infections à coronavirus, Pandémies, Pneumopathie virale, Pronostic, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- etiology : Acute Kidney Injury.
- Betacoronavirus, Humans, Pandemics, Prognosis, ROC Curve, Retrospective Studies, Risk Factors.
Abstract
OBJECTIVE
To investigate the characteristics and the risk factors of coronavirus disease 2019 (COVID-19) associated acute kidney injury (AKI).
METHODS
A retrospective cohort study was performed to examine the basic data, clinical characteristics and prognosis of patients with COVID-19 in Zhongnan Hospital of Wuhan University and Wuhan Fourth Hospital from January 1st to February 1st in 2020. According to the diagnostic criteria of Kidney Disease: Improving Global Outcomes (KDIGO), patients with AKI were included in AKI group and those without AKI were included in non-AKI group. The differences of each index between the two groups were compared. The prognostic value of AKI for COVID-19 was analyzed by Kaplan-Meier survival curve and Cox regression.
RESULTS
A total of 394 COVID-19 patients were included, with a total mortality of 5.6%; 37 (9.4%) of them developed AKI. The mortality of patients with COVID-19 associated AKI was 18.9%. There were significant differences in age, gender, smoking history, hypertension history, malignancy history, cardiovascular disease history and cerebrovascular disease history between the two groups. In addition to the difference of serum creatinine (SCr) and blood urea nitrogen (BUN), white blood cell count (WBC), neutrophil count (NEU), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D-dimer, procalcitonin (PCT) and C-reaction protein (CRP) in AKI group were significantly higher than those in non-AKI group [WBC (×10
CONCLUSIONS
The risk of AKI is higher in patients with COVID-19. Early intervention to prevent AKI in patients with COVID-19 is of great significance to improve the prognosis of patients.
DOI: 10.3760/cma.j.cn121430-20200302-00198
PubMed: 32527342
Affiliations:
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Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Su, Lianjiu" sort="Su, Lianjiu" uniqKey="Su L" first="Lianjiu" last="Su">Lianjiu Su</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jie" sort="Yang, Jie" uniqKey="Yang J" first="Jie" last="Yang">Jie Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Xiaofang" sort="Jiang, Xiaofang" uniqKey="Jiang X" first="Xiaofang" last="Jiang">Xiaofang Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Nanhui" sort="Jiang, Nanhui" uniqKey="Jiang N" first="Nanhui" last="Jiang">Nanhui Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Yu" sort="Lei, Yu" uniqKey="Lei Y" first="Yu" last="Lei">Yu Lei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Qiaofa" sort="Lu, Qiaofa" uniqKey="Lu Q" first="Qiaofa" last="Lu">Qiaofa Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Sanying" sort="Shen, Sanying" uniqKey="Shen S" first="Sanying" last="Shen">Sanying Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Fan" sort="Chen, Fan" uniqKey="Chen F" first="Fan" last="Chen">Fan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Zhiyong" sort="Peng, Zhiyong" uniqKey="Peng Z" first="Zhiyong" last="Peng">Zhiyong Peng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32527342</idno><idno type="pmid">32527342</idno><idno type="doi">10.3760/cma.j.cn121430-20200302-00198</idno><idno type="wicri:Area/Main/Corpus">000162</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000162</idno><idno type="wicri:Area/Main/Curation">000162</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000162</idno><idno type="wicri:Area/Main/Exploration">000162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019].</title><author><name sortKey="Zhang, Jiahao" sort="Zhang, Jiahao" uniqKey="Zhang J" first="Jiahao" last="Zhang">Jiahao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Su, Lianjiu" sort="Su, Lianjiu" uniqKey="Su L" first="Lianjiu" last="Su">Lianjiu Su</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jie" sort="Yang, Jie" uniqKey="Yang J" first="Jie" last="Yang">Jie Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Xiaofang" sort="Jiang, Xiaofang" uniqKey="Jiang X" first="Xiaofang" last="Jiang">Xiaofang Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Nanhui" sort="Jiang, Nanhui" uniqKey="Jiang N" first="Nanhui" last="Jiang">Nanhui Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Yu" sort="Lei, Yu" uniqKey="Lei Y" first="Yu" last="Lei">Yu Lei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Qiaofa" sort="Lu, Qiaofa" uniqKey="Lu Q" first="Qiaofa" last="Lu">Qiaofa Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Sanying" sort="Shen, Sanying" uniqKey="Shen S" first="Sanying" last="Shen">Sanying Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Fan" sort="Chen, Fan" uniqKey="Chen F" first="Fan" last="Chen">Fan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong</wicri:regionArea><wicri:noRegion>China. Corresponding author: Peng Zhiyong</wicri:noRegion></affiliation></author><author><name sortKey="Peng, Zhiyong" sort="Peng, Zhiyong" uniqKey="Peng Z" first="Zhiyong" last="Peng">Zhiyong Peng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Zhonghua wei zhong bing ji jiu yi xue</title><idno type="ISSN">2095-4352</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (etiology)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Prognosis (MeSH)</term><term>ROC Curve (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Atteinte rénale aigüe (étiologie)</term><term>Betacoronavirus (MeSH)</term><term>Courbe ROC (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pronostic (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Acute Kidney Injury</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Atteinte rénale aigüe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>Humans</term><term>Pandemics</term><term>Prognosis</term><term>ROC Curve</term><term>Retrospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Betacoronavirus</term><term>Courbe ROC</term><term>Facteurs de risque</term><term>Humains</term><term>Infections à coronavirus</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Pronostic</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To investigate the characteristics and the risk factors of coronavirus disease 2019 (COVID-19) associated acute kidney injury (AKI).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A retrospective cohort study was performed to examine the basic data, clinical characteristics and prognosis of patients with COVID-19 in Zhongnan Hospital of Wuhan University and Wuhan Fourth Hospital from January 1st to February 1st in 2020. According to the diagnostic criteria of Kidney Disease: Improving Global Outcomes (KDIGO), patients with AKI were included in AKI group and those without AKI were included in non-AKI group. The differences of each index between the two groups were compared. The prognostic value of AKI for COVID-19 was analyzed by Kaplan-Meier survival curve and Cox regression.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 394 COVID-19 patients were included, with a total mortality of 5.6%; 37 (9.4%) of them developed AKI. The mortality of patients with COVID-19 associated AKI was 18.9%. There were significant differences in age, gender, smoking history, hypertension history, malignancy history, cardiovascular disease history and cerebrovascular disease history between the two groups. In addition to the difference of serum creatinine (SCr) and blood urea nitrogen (BUN), white blood cell count (WBC), neutrophil count (NEU), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D-dimer, procalcitonin (PCT) and C-reaction protein (CRP) in AKI group were significantly higher than those in non-AKI group [WBC (×10</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The risk of AKI is higher in patients with COVID-19. Early intervention to prevent AKI in patients with COVID-19 is of great significance to improve the prognosis of patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32527342</PMID><DateCompleted><Year>2020</Year><Month>06</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2095-4352</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Zhonghua wei zhong bing ji jiu yi xue</Title><ISOAbbreviation>Zhonghua Wei Zhong Bing Ji Jiu Yi Xue</ISOAbbreviation></Journal><ArticleTitle>[Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019].</ArticleTitle><Pagination><MedlinePgn>407-411</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3760/cma.j.cn121430-20200302-00198</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the characteristics and the risk factors of coronavirus disease 2019 (COVID-19) associated acute kidney injury (AKI).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective cohort study was performed to examine the basic data, clinical characteristics and prognosis of patients with COVID-19 in Zhongnan Hospital of Wuhan University and Wuhan Fourth Hospital from January 1st to February 1st in 2020. According to the diagnostic criteria of Kidney Disease: Improving Global Outcomes (KDIGO), patients with AKI were included in AKI group and those without AKI were included in non-AKI group. The differences of each index between the two groups were compared. The prognostic value of AKI for COVID-19 was analyzed by Kaplan-Meier survival curve and Cox regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 394 COVID-19 patients were included, with a total mortality of 5.6%; 37 (9.4%) of them developed AKI. The mortality of patients with COVID-19 associated AKI was 18.9%. There were significant differences in age, gender, smoking history, hypertension history, malignancy history, cardiovascular disease history and cerebrovascular disease history between the two groups. In addition to the difference of serum creatinine (SCr) and blood urea nitrogen (BUN), white blood cell count (WBC), neutrophil count (NEU), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D-dimer, procalcitonin (PCT) and C-reaction protein (CRP) in AKI group were significantly higher than those in non-AKI group [WBC (×10<sup>9</sup>/L): 5.75 (4.13, 7.83) vs. 4.52 (3.35, 5.90), NEU (×10<sup>9</sup>/L): 4.55 (2.81, 6.11) vs. 3.06 (2.03, 4.50), AST (U/L): 40.0 (24.5, 69.5) vs. 30.0 (23.0, 42.5), LDH (μmol×s<sup>-1</sup>×L<sup>-1</sup>): 5.21 (3.68, 7.57) vs. 4.24 (3.05, 5.53), D-dimer (μg/L): 456 (266, 2 172) vs. 290 (152, 610), PCT (μg/L): 0.33 (0.03, 1.52) vs. 0.01 (0.01, 0.11), CRP (mg/L): 53.80 (26.00, 100.90) vs. 23.60 (9.25, 51.10), all P < 0.05], while lymphocyte count (LYM) and platelet count (PLT) were decreased [LYM (×10<sup>9</sup>/L): 0.68 (0.47, 1.05) vs. 0.91 (0.63, 1.25), PLT (×10<sup>9</sup>/L): 142.0 (118.0, 190.0) vs. 171.0 (130.0, 2 190.0), both P < 0.05]. The mortality of AKI group was significantly higher than that of non-AKI group [18.9% (7/37) vs. 4.2% (15/357), P < 0.01]. Kaplan-Meier survival curve showed that the 30-day cumulative survival of AKI group was lower than that of non-AKI group (log-rank: P = 0.003). Cox analysis also showed that AKI increased the odds of patients with COVID-19 mortality by 3.2-fold [hazard ratio (HR) = 3.208, 95% confidence interval (95%CI) was 1.076-9.566, P = 0.037].</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The risk of AKI is higher in patients with COVID-19. Early intervention to prevent AKI in patients with COVID-19 is of great significance to improve the prognosis of patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jiahao</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Lianjiu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Xiaofang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Nanhui</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lei</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Qiaofa</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Sanying</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Wuhan Fourth Hospital, Wuhan 430000, Hubei, China. Corresponding author: Peng Zhiyong, Email: pengzy5@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430000, Hubei, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Wei Zhong Bing Ji Jiu Yi Xue</MedlineTA><NlmUniqueID>101604552</NlmUniqueID></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="Y">Acute Kidney Injury</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32527342</ArticleId><ArticleId IdType="doi">10.3760/cma.j.cn121430-20200302-00198</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Oman</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Jiahao" sort="Zhang, Jiahao" uniqKey="Zhang J" first="Jiahao" last="Zhang">Jiahao Zhang</name></noRegion><name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name><name sortKey="Jiang, Nanhui" sort="Jiang, Nanhui" uniqKey="Jiang N" first="Nanhui" last="Jiang">Nanhui Jiang</name><name sortKey="Jiang, Xiaofang" sort="Jiang, Xiaofang" uniqKey="Jiang X" first="Xiaofang" last="Jiang">Xiaofang Jiang</name><name sortKey="Peng, Zhiyong" sort="Peng, Zhiyong" uniqKey="Peng Z" first="Zhiyong" last="Peng">Zhiyong Peng</name><name sortKey="Su, Lianjiu" sort="Su, Lianjiu" uniqKey="Su L" first="Lianjiu" last="Su">Lianjiu Su</name></country><country name="Oman"><noRegion><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name></noRegion><name sortKey="Chen, Fan" sort="Chen, Fan" uniqKey="Chen F" first="Fan" last="Chen">Fan Chen</name><name sortKey="Lei, Yu" sort="Lei, Yu" uniqKey="Lei Y" first="Yu" last="Lei">Yu Lei</name><name sortKey="Lu, Qiaofa" sort="Lu, Qiaofa" uniqKey="Lu Q" first="Qiaofa" last="Lu">Qiaofa Lu</name><name sortKey="Shen, Sanying" sort="Shen, Sanying" uniqKey="Shen S" first="Sanying" last="Shen">Sanying Shen</name><name sortKey="Yang, Jie" sort="Yang, Jie" uniqKey="Yang J" first="Jie" last="Yang">Jie Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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